Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/1457
Title: Alterations in the coupling functions between cortical and cardio-respiratory oscillations due to anaesthesia with propofol and sevoflurane
Authors: Stankovski, Tomislav 
Petkoski, Spase
Raeder, Johan
Smith, Andrew F
McClintock, Peter V E
Stefanovska, Aneta
Issue Date: 13-May-2016
Publisher: The Royal Society
Journal: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Abstract: The precise mechanisms underlying general anaesthesia pose important and still open questions. To address them, we have studied anaesthesia induced by the widely used (intravenous) propofol and (inhalational) sevoflurane anaesthetics, computing cross-frequency coupling functions between neuronal, cardiac and respiratory oscillations in order to determine their mutual interactions. The phase domain coupling function reveals the form of the function defining the mechanism of an interaction, as well as its coupling strength. Using a method based on dynamical Bayesian inference, we have thus identified and analysed the coupling functions for six relationships. By quantitative assessment of the forms and strengths of the couplings, we have revealed how these relationships are altered by anaesthesia, also showing that some of them are differently affected by propofol and sevoflurane. These findings, together with the novel coupling function analysis, offer a new direction in the assessment of general anaesthesia and neurophysiological interactions, in general.
URI: http://hdl.handle.net/20.500.12188/1457
ISSN: 1364-503X
DOI: 10.1098/rsta.2015.0186
Appears in Collections:Faculty of Medicine: Journal Articles

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