Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/11815
Title: Heterotopia or overlaying cortex: What about in-between?
Authors: Cvetkovska, Emilija 
Martins, William Alves
Gonzalez-Martinez, Jorge
Taylor, Ken
Li, Jian
Grinenko, Olesya
Mosher, John
Leahy, Richard
Chauvel, Patrick
Nair, Dileep
Issue Date: 2019
Publisher: Elsevier BV
Journal: Epilepsy & Behavior Case Reports
Abstract: We describe a patient with unilateral periventricular nodular heterotopia (PNH) and drug-resistant epilepsy, whose SEEG revealed that seizures were arising from the PNH, with the almost simultaneous involvement of heterotopic neurons ("micronodules") scattered within the white matter, and subsequently the overlying cortex. Laser ablation of heterotopic nodules and the adjacent white matter rendered the patient seizure free. This case elucidates that "micronodules" scattered in white matter between heterotopic nodules and overlying cortex might be another contributor in complex epileptogenicity of heterotopia. Detecting patient-specific targets in the epileptic network of heterotopia creates the possibility to disrupt the pathological circuit by minimally invasive procedures.
URI: http://hdl.handle.net/20.500.12188/11815
ISSN: 2213-3232
DOI: 10.1016/j.ebcr.2018.09.007
Appears in Collections:Faculty of Medicine: Journal Articles

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