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Title: Correlation of cervical length, fetal fibronectin, phIGFBP-1, and cytokines in spontaneous preterm birth up to 14 days from sampling
Authors: Marija Hadži-Lega
Ana Daneva Markova 
Milan Stefanovic
Mile Tanturovski 
Keywords: cervical length
predictive value
preterm birth
Issue Date: Dec-2014
Publisher: De Gryter
Journal: Journal of Perinatal Medicine
Abstract: Abstract Objective: The aim of this study was to determine the relationship between sonographic cervical length, fetal fibronectin (fFN), phIGFBP-1 (actim partus test), cytokines (IL-6, IL-2R, and TNF- α ), and spontaneous preterm birth (SPTB) up to 14 days from sampling. Methods: Fifty-eight patients were recruited in a period of 6 months from September 2013 until March 2014 with symptoms or complaints suggestive of preterm labor. Consenting women were treated according to usual hospital protocol, with addition of vaginal swabs taken for fetal fibronectin, phIGFBP-1 (actim partus test) and cervical IL6, IL2R, and TNF- α . The outcome variable was occurrence of preterm delivery within 14 days from the day of hospital admission. Results: Thirty-six patients (62.07%) were delivered within 14 days from admission. Our results indicated that the cervical length significantly inversely correlates with the concentration of IL-6 in the CVF (Spearman ’ s coefficient R = – 0.382, P < 0.05). Cervical length also correlated with a positive phIGFBP-1 test, i.e., patients with a positive test had an average cervical length of 18.5 ± 4.63 mm, which is significantly lower than patients with a negative test – 23.43 ± 7.39 mm (P = 0.003). Conclusions: The studied biochemical markers were only moderately successful in the prediction of preterm delivery.
Appears in Collections:Faculty of Medicine: Journal Articles

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