Correlation of cervical length, fetal fibronectin, phIGFBP-1, and cytokines in spontaneous preterm birth up to 14 days from sampling
Journal
Journal of Perinatal Medicine
Date Issued
2014-12
Author(s)
Stefanovic, Milan
DOI
https://doi.org/10.1515/jpm-2014-0275
Abstract
Abstract
Objective: The aim of this study was to determine the
relationship between sonographic cervical length, fetal
fibronectin (fFN), phIGFBP-1 (actim partus test), cytokines
(IL-6, IL-2R, and TNF- α ), and spontaneous preterm birth
(SPTB) up to 14 days from sampling.
Methods: Fifty-eight patients were recruited in a period
of 6 months from September 2013 until March 2014 with
symptoms or complaints suggestive of preterm labor. Consenting
women were treated according to usual hospital
protocol, with addition of vaginal swabs taken for fetal
fibronectin, phIGFBP-1 (actim partus test) and cervical
IL6, IL2R, and TNF- α . The outcome variable was occurrence
of preterm delivery within 14 days from the day of
hospital admission.
Results: Thirty-six patients (62.07%) were delivered
within 14 days from admission. Our results indicated that
the cervical length significantly inversely correlates with
the concentration of IL-6 in the CVF (Spearman ’ s coefficient
R = – 0.382, P < 0.05). Cervical length also correlated
with a positive phIGFBP-1 test, i.e., patients with a positive
test had an average cervical length of 18.5 ± 4.63 mm,
which is significantly lower than patients with a negative
test – 23.43 ± 7.39 mm (P = 0.003).
Conclusions: The studied biochemical markers were
only moderately successful in the prediction of preterm
delivery.
Objective: The aim of this study was to determine the
relationship between sonographic cervical length, fetal
fibronectin (fFN), phIGFBP-1 (actim partus test), cytokines
(IL-6, IL-2R, and TNF- α ), and spontaneous preterm birth
(SPTB) up to 14 days from sampling.
Methods: Fifty-eight patients were recruited in a period
of 6 months from September 2013 until March 2014 with
symptoms or complaints suggestive of preterm labor. Consenting
women were treated according to usual hospital
protocol, with addition of vaginal swabs taken for fetal
fibronectin, phIGFBP-1 (actim partus test) and cervical
IL6, IL2R, and TNF- α . The outcome variable was occurrence
of preterm delivery within 14 days from the day of
hospital admission.
Results: Thirty-six patients (62.07%) were delivered
within 14 days from admission. Our results indicated that
the cervical length significantly inversely correlates with
the concentration of IL-6 in the CVF (Spearman ’ s coefficient
R = – 0.382, P < 0.05). Cervical length also correlated
with a positive phIGFBP-1 test, i.e., patients with a positive
test had an average cervical length of 18.5 ± 4.63 mm,
which is significantly lower than patients with a negative
test – 23.43 ± 7.39 mm (P = 0.003).
Conclusions: The studied biochemical markers were
only moderately successful in the prediction of preterm
delivery.