Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/10718
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dc.contributor.authorMirjana Kocovaen_US
dc.contributor.authorNikolina Zdraveskaen_US
dc.contributor.authorElena Sukarova-Angelovskaen_US
dc.date.accessioned2021-03-08T14:48:45Z-
dc.date.available2021-03-08T14:48:45Z-
dc.date.issued2011-
dc.identifier.issn0334-018X-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/10718-
dc.description.abstractHypothalamic hamartomas (HH) are rare congenital nonneoplastic lesions of the tuber cinereum, which usually present as precocious puberty of central origin in young girls and respond well to treatment with long acting gonadotropin releasing hormone (GnRH) analogs. No association of this condition with diabetes mellitus of any form has been reported so far. On the other hand, diabetes mellitus in children and adolescents, when it is not autoimmune type 1 diabetes, is difficult to classify. We present a girl with early onset of central precocious puberty at the age of 8 months, due to hypothalamic hamartoma. Treatment with depot of a GnRH analog for a period of 9 years and 8 months was successful, and her puberty continued 6 months after the discontinuation of triptorelin. At the age of 9 years 6 months, the girl presented with diabetes. She was negative for islet, GAD and IA2 antibodies and her insulinemia and C-peptide remained within normal limits during the 2 years of follow-up. Her metabolic control is excellent with a combination of metformin and a low-dose of mixed insulin. To our knowledge, this is the first description of the simultaneous appearance of these two endocrinological conditions.en_US
dc.language.isoenen_US
dc.publisherWalter de Gruyter GmbHen_US
dc.relation.ispartofJournal of Pediatric Endocrinology and Metabolismen_US
dc.titleUnique concurrent appearance of two rare conditions in a young girl: central precocious puberty due to hypothalamic hamartoma and uncommon type of diabetesen_US
dc.typeArticleen_US
dc.identifier.doi10.1515/jpem.2011.192-
dc.identifier.urlhttps://www.degruyter.com/view/j/jpem.2011.24.issue-9-10/jpem.2011.192/jpem.2011.192.pdf-
dc.identifier.volume24-
dc.identifier.issue9-10-
item.grantfulltextnone-
item.fulltextNo Fulltext-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
Appears in Collections:Faculty of Medicine: Journal Articles
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