Accuracy of functional methods for detecting coronary artery disease with asymmetric dimethylarginine (adma), myocardial perfusion scintigraphy, or both as shifted test in detecting asymptomatic endothelial dysfunction in patients with systemic lupus erythematosus

Abstract

Introduction. The purpose of this research was to compare the diagnostic values of laboratory variables, to present quantitative evaluations of the diagnostic test with reference to sensitivity, and specificity, the predictive value of the positive and negative test and precision of the test for Asymmetric dimethylarginine (ADMA), assessed with myocardial perfusion scintigraphy (MPS), acute phase reactant, in early diagnosis of untreated Systemic Lupus Erythematosus (SLE), to determine whether ADMA changes depend on the disease evolution. ADMA is used as an indicator for endothelial dysfunction. Methods. Using the ELISA technology of DLD-Diagnostika-GMBH, ADMA, the serum has been examined in 70 participants (35 SLE who were not treated, 35 controls). In the same time we determined the sensitivity, specificity, predictive value for positive and negative test and accuracy. Results. Out of 35 examined patients with SLE, in 13 we found the presence of ADMA (sensitivity of the test 37.14%). Myocardial Perfusion Scintigraphy appeared in 17 patients (sensitivity of the test 48.57%). Four patients were ADMA and MPS positive. Among 18 MPS negative patients, 9 patients were ADMA positive. Among 17 MPS positive SLE, the presence of ADMA was found in 4 patients. Among 18 MPS negative SLE, ADMA appeared in 9 patients. In the healthy control group, 8 patients were ADMA positive. Conclusion. ADMA has low sensitivity, but high specificity from MPS at untreated SLE with coronary artery disease